AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD
Shuai Wang, Sophia Zhao, Adam Daniels, Efrat Naaman, Apolonia Gardner, Tianxi Wang, Ye Sun, Zhongjie Fu, Lois E. H. Smith, Constance L. Cepko
This study shows that AAV-NRF2 protects retinal and choroidal vasculature in an oxidative damage model of AMD through GDF15, reducing inflammation and oxidative stress.
Proceedings of the National Academy of Sciences · Aug 11, 2026Peer-reviewedCell Biology