Author

Lois E. H. Smith

Boston Children's HospitalORCID 0000-0001-7644-6410Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Zhongjie FuiD· 2 shared Adam Daniels· 1 shared Alexandre DubraciD· 1 shared Andrew KuoiD· 1 shared Anli Ren· 1 shared Antonio ChecaiD· 1 shared Anu Situ· 1 shared Apolonia GardneriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

Zhongjie FuORCID

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3 papers

Recent·Most cited

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedAug 11, 2026

AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD

Shuai Wang, Sophia Zhao, Adam Daniels…·Constance L. Cepko

This study shows that AAV-NRF2 protects retinal and choroidal vasculature in an oxidative damage model of AMD through GDF15, reducing inflammation and oxidative stress.

1 citationtop 3%

mousebulk RNA-seq

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Cell BiologyNature CommunicationsPeer-reviewedJun 25, 2025

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy

Gaël Cagnone, Sheetal Pundir, Charlotte Betus…·Jean‐Sébastien Joyal

This study shows that metabolic reprogramming in the neurovascular niche promotes regenerative angiogenesis in proliferative retinopathy by shifting metabolism from fatty acid oxidation to glycolysis.

16 citationstop 1%

humanmouse

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Developmental BiologyeLifePeer-reviewedOct 5, 2022

Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis

Andrew Kuo, Antonio Checa, Colin Niaudet…·Timothy Hla

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

19 citations

mouseexperimental assay

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