Type II topoisomerase substrate geometry revealed through combined experiment and computation.
Mihir Prajapati, Yeonee Seol, Jonathan E. Silver, Parth Rakesh Desai, Siddhartha Das, Keir Cajal Neuman
This study determines the 3D geometry of DNA crossings preferred for strand passage by topo II enzymes using single-molecule experiments and simulations.
bioRxiv · Sep 8, 2026 · PreprintBiophysics