Gábor M. Harami

This study shows that TOP3 resolves both inter- and intra-molecular DNA intertwines during replication, promoting fork progression and daughter strand unlinking, especially when TOP2 is compromised.

This study shows hSSB1 undergoes redox-dependent LLPS to form cytoplasmic granules involved in oxidative stress response and genome repair.

This study develops SHAN-seq to map type II topoisomerase cleavage sites on DNA with high sensitivity, revealing hundreds of sites and enzyme-specific variations.

This study shows human SSB2 forms phase separation condensates requiring ssDNA binding, revealing evolutionary adaptations in genome repair mechanisms compared to E. coli SSB.

This study creates and characterizes a zebrafish model for Bloom syndrome, showing that blm mutants exhibit shortened lifespan, reduced fertility, and germ line developmental issues.