Author

Yi Shu

Merck & Co., Inc., Rahway, NJ, USA (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant calling· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christopher Warren· 1 shared Dai WangiD· 1 shared Daphne Ma· 1 shared Eberhard DürriD· 1 shared Emmanuel NdashimyeiD· 1 shared Feng LuoiD· 1 shared Hong-Dong LiiD· 1 shared Jason S. McLellaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Christopher Warren

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2 papers

Recent·Most cited

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens

Madeline R. Sponholtz, Daphne Ma, Emmanuel Ndashimye, Patrick O. Byrne, Yi Shu, Christopher Warren, Nithya Thambi, Ryan S. McCool, Matthew D. Slein, Nicole V. Johnson, William A. Rose, Lan Zhang, Eberhard Dürr, Dai Wang, Jason S. McLellan

This study designs prefusion-stabilized HSV-2 gB antigens using structure-based methods and evaluates their immunogenicity, finding no improvement in neutralizing antibody titers compared to postfusion constructs.

Cell Reports · Sep 1, 2026Peer-reviewedMicrobiology

Unimeth: A unified transformer framework for accurate DNA methylation detection from nanopore reads

Shaokai Wang, Peng Ni, Yifu Xiao, Tao Sheng, Neng Huang, Yi Shu, Hong-Dong Li, Lu Shen, Xiao-Xin Yan, Jixian Zhai, Feng Luo, Jianxin Wang

Unimeth improves DNA methylation detection from nanopore reads across species and modification types by using a transformer framework with multi-phase training.

bioRxiv · May 28, 2026 · PreprintBioinformatics