Author

Yi Xiao

Children's Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alpaslan TasdoganiD· 1 shared Ashley Rowe· 1 shared Ashley SolmonsoniD· 1 shared Aundrea K. WestfalliD· 1 shared Brandon FaubertiD· 1 shared Bushra AfrozeiD· 1 shared Fei Chen· 1 shared Feng CaiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Alpaslan TasdoganORCID

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2 papers

Recent·Most cited

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

Wen Gu, Xun Wang, Ashley Solmonson, Ling Cai, Yi Xiao, Alpaslan Tasdogan, Jordan Franklin, Yuannyu Zhang, Hua Zhang, Aundrea K. Westfall, Ashley Rowe, H S Trivedi, Brandon Faubert, Zheng Wu, Jessica Sudderth, , Ralph J. DeBerardinis

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

Journal of Clinical Investigation · Mar 17, 2026Peer-reviewedGenetics

Klf4 methylated by Prmt1 is required for lineage segregation of epiblast and primitive endoderm

Zhenyu Zuo, Guanghui Yang, Haiyu Wang, Shuyu Liu, Yanjun Zhang, Yun Cai, Fei Chen, Hui Dai, Yi Xiao, Mo-Bin Cheng, Yue Huang, Ye Zhang

This study identifies Prmt1-mediated Klf4 methylation as critical for lineage segregation between epiblast and primitive endoderm in mouse embryos.

Nucleic Acids Research · Jan 25, 2022Peer-reviewedMolecular Biology