Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stress
Yiling Ge, Yong Liu, Bin Zhang, Jin Xu, Si-Yuan He, Qing-Lin Cao, Pei-Jie Li, Ying-Rui Bu, Yungang Bai, Lin Zhang, Zhi‐Bin Yu, Man‐Jiang Xie
This study identifies Bmal1 activation as a driver of mitochondrial stress and inflammation in monocytes under hypobaric hypoxia, mediated by BHLHE40 and Fis1-mediated mitochondrial fission.
bioRxiv · Apr 2, 2024 · PreprintMolecular Biology