Molecular BiologybioRxivPreprint
Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stress
Yiling Ge, Yong Liu, Bin Zhang…·Man‐Jiang Xie
This study identifies Bmal1 activation as a driver of mitochondrial stress and inflammation in monocytes under hypobaric hypoxia, mediated by BHLHE40 and Fis1-mediated mitochondrial fission.