Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safety
Dan Wu, Zhen Gong, Ying He, Sandeep Kumar, Venkateswararao Eeda, Qianfen Wan, Oana Herlea-Pana, Hui-Ying Lim, Wayne A. Hendrickson, Li Qiang, Weidong Wang
This paper identifies a small molecule inhibitor of PPARγ acetylation that improves insulin sensitivity and browning of white adipose tissue without the side effects of traditional PPARγ agonists.
bioRxiv · Dec 16, 2025 · PreprintCell Biology