Ying Yang

CD4 T cell surface architecture is associated with response to anti-PD-1 therapy in non-small cell lung cancer

The paper shows that CD4 T cell surface protein organization predicts response to anti-PD-1 therapy in NSCLC, outperforming protein abundance alone.

BioMod: Biological Module Tokenization for Single-Cell Foundation Modeling

BioMod introduces biological modules as intermediate units for single-cell foundation modeling, achieving state-of-the-art performance in cell-type annotation and drug-response prediction.

Neural mechanisms of impaired self-compassion in depressed adolescents during social exclusion

This study investigates neural mechanisms of impaired self-compassion in depressed adolescents during social exclusion using event-related potentials.

Targeting NAT10 suppresses TFH responses and alleviates allergic asthma via an ac4C-TOX2 axis

This study identifies NAT10 as a regulator of TFH cell differentiation through the acC-TOX2 axis, showing that targeting NAT10 suppresses allergic asthma in mice.

Neurocognitive deficits in controlling aversive memory among insomnia disorders

This study investigates memory control impairments in insomnia disorder, finding reduced suppression-induced forgetting and altered electrophysiological responses during memory suppression tasks.

Bioinformatic analysis of metastasis-associated metabolic landscape reveals an oncogenic role for the transsulfuration pathway

The paper identifies the transsulfuration pathway as an oncogenic driver in pancreatic cancer metastasis through metabolomic analysis and functional validation.

Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failure

This study identifies novel genetic risk loci and potential drugs for heart failure using multi-trait genome-wide analysis of GWAS data.