rDNA breaks activate dsRNA pattern recognition through sense-antisense transcription
Jie Chen, Sangin Kim, Sixing Chen, Zongchao Mo, Yiyang Jiang, Kathy F. Liu, Qin Li, Roger A. Greenberg
The paper shows that rDNA breaks generate sense-antisense rRNA transcripts that activate immune signaling via MDA5 and RIG-I.
bioRxiv · May 28, 2026 · PreprintCell Biology