Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments
Jie Chen, Zongchao Mo, Sixing Chen, Xi Wang, Tiffany Y. T. Hsu, Celia Torres-Arancivia, Kathy Fange Liu, Sun Hur, Qin Li, Roger A. Greenberg
The paper identifies immunogenic endogenous dsRNAs by isolating MDA5 filaments and shows their suppression by ADAR1 and DDX3X.
bioRxiv · Jun 8, 2026 · PreprintCell Biology