Yong Li

Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature

The paper investigates the thermodynamic effects of the Y220C TP53 mutation on Zn2+-binding and shows that Rezatapopt restores Zn2+-affinity through two pathways.

Prenatal e-cigarette exposure induces region- and cell type-specific metabolic and developmental reprogramming

This study shows prenatal e-cigarette exposure causes region- and cell type-specific metabolic and developmental changes in neonatal rat brains, linked to neurodevelopmental disease risk.

FLEX: A heparin-binding fusion partner engineered from fibroblast growth factor 1 to enhance protein expression, solubility and purity

This paper introduces FLEX, a fusion tag derived from FGF1 that enhances protein expression, solubility, and purity across different systems.

Cardiac PIEZO 1 Channels Modulate Anxiety

This study investigates how PIEZO 1 channels in cardiac sensory neurons modulate anxiety by affecting interoception and predictive coding.

Discovery and characterization of FX-909, a covalent inverse agonist of PPARG rationally designed to impose a powerful repressive bias in PPARG for the treatment of PPARG/RXRA-activated muscle-invasive urothelial cancers

Intratumor Heterogeneity and Evolution of Colorectal Cancer

This study examines intratumor heterogeneity and evolution patterns in colorectal cancer, finding a Darwinian pattern with differences between right-sided and left-sided tumors.

Changes in Microorganisms in the Rhizosphere of Mulberry Genotypes with Differing Resistance to Bacterial Wilt

This study compares microbial abundance, community structure, and functional diversity in the rhizosphere of resistant and susceptible mulberry genotypes to understand bacterial wilt resistance mechanisms.