Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression
Xianhui Liu, Yao D. Cai, Chunyan Hou, Xu Liu, Youcheng Luo, Aron Judd P. Mendiola, Xuehan Xu, Yige Luo, Haiyan Zheng, Caifeng Zhao, Ching‐Hsuan Chen, Yong Zhang, Yang K. Xiang, Junfeng Ma, Joanna C. Chiu
This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.
PLoS Biology · Sep 25, 2025Peer-reviewedPhysiology