A Sequential Assembly Mechanism for Stable Cdc13 Dimerization on Telomeric DNA
Po-Wei Chiu, Yu Lin, Pei-Ru Lai, Tzu-Yu Lee, Yu‐Chen Cheng, Yan-Zhu Hsieh, Hung‐Wen Li, Jing-Jer Lin
This study shows Cdc13 initially binds telomeres as a monomer, then forms a stable dimer, revealing a sequential mechanism for telomere protection and length regulation.
bioRxiv · Sep 2, 2026 · PreprintBiophysics