Yue Hou

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation

This study identifies molecular and immune mechanisms driving malignant transformation from inverted papilloma to sinonasal squamous cell carcinoma using multi-omics analyses.

YY1 Enhances the Stability of HIF-1α Protein by Interacting with NUSAP1 in Macrophages within the Prostate Cancer Microenvironment

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

Novel Roles of G-quadruplexes on Enhancers in human chromatin

This study identifies G-quadruplexes on enhancers as regulators of chromatin structure and enhancer activity by promoting nucleosome depletion and TF recruitment.

TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics

TASI quantifies tumor spheroid dynamics through spatiotemporal segmentation, feature extraction, modeling, and statistical analysis, demonstrating its utility in analyzing non-small cell lung cancer spheroids.

Overlooked polyploidies in lycophytes generalize their roles during the evolution of vascular plants

The paper reanalyzes the genome of Selaginella moellendroffii and finds multiple polyploidies, suggesting they played a key role in the evolution of vascular plants.