Jing Li

Endonuclease G governs an antiviral RNA surveillance system in budding yeast

This study identifies Nuc1, a mitochondrial enzyme, as a regulator of an RNA surveillance system in yeast that limits replication of the L-A mycovirus.

Multi-scale spatial transcriptomic atlas of the whole mouse spinal cord

The paper creates a spatial transcriptomic atlas of the whole mouse spinal cord, revealing multi-scale cellular organization and gene-expression patterns across different regions.

Direct mitochondrial import of lactate supports resilient carbohydrate oxidation

This study shows that lactate can be directly imported into mitochondria and oxidized to support cardiac energy production, independent of the pyruvate carrier.

Task-based value generalization correlates with positive overgeneralization and bipolar traits

This study introduces a behavioral paradigm to measure reward generalization and links broader generalization to positive overgeneralization and subclinical bipolar traits.

Conformational Preference Classification of Integrin-Binding Ligands Using Free Energy Perturbation

This paper presents AB-FEP, a computational method to classify integrin-binding ligands by their conformational preference, showing high accuracy and insights into ligand mechanisms.

Expression of immune checkpoint VISTA represents a differentiated state of cancer cells and plays a role in regulating actin cytoskeleton

This study shows that high VISTA expression in cancer cells indicates a less malignant state and affects actin cytoskeleton, suggesting immune checkpoints may have non-immunological roles in cancer.

FoTO1 is an epoxide isomerase in paclitaxel biosynthesis

This study identifies FoTO1 as an epoxide isomerase that facilitates the productive rearrangement of taxadiene-4(5)-epoxide in paclitaxel biosynthesis.

Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology

This study shows cPLA2 overactivation is linked to synaptic loss and cognitive decline in Alzheimer's disease through increased eicosanoids and altered synaptic marker interactions.

Kinetic Control of Out-Of-Equilibrium Dynamics in the RhoA Signaling Cascade Shapes Actomyosin Contractility

The paper investigates the kinetic delays in the RhoA signaling cascade during actomyosin contractility in C. elegans embryos and shows they actively control force deployment.

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution

The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.

Identification of a new ORF3a-E fusion subgenomic RNA of SARS-CoV-2 and its biological features in the infection process

The paper identifies a new SARS-CoV-2 subgenomic RNA, ORF3a-E-sgRNA, which enhances viral replication and immune evasion by promoting translation and host protein interactions.

Discovery of a new evolutionarily conserved short linear F-actin binding motif

The paper identifies a new evolutionarily conserved short linear F-actin binding motif and develops a computational pipeline to identify its containing proteins.

In vivo two-photon FLIM resolves photosynthetic properties of maize bundle sheath cells

This study uses two-photon FLIM to analyze photosynthetic properties of maize bundle sheath cells in vivo, revealing reduced PSII activity and acetic acid-induced fluorescence quenching.

Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease

The paper identifies a pathobiont-epithelial IDO1 pathway that drives region-specific susceptibility to inflammatory bowel disease in the ascending colon.

Cytochrome P450 Enzyme Design by Constraining Catalytic Pocket in Diffusion model

The paper designs artificial cytochrome P450 enzymes by applying a 'three-point fixation' model derived from structural and evolutionary analysis, resulting in enzymes with enhanced catalytic activity.

miR-199-3p Suppresses Cellular Migration and Viability and Promotes Progesterone Production in Goose Ovarian Follicles Before Selection by Targeting ITGB8 and Regulating Other ECM-related Genes

This study shows miR-199-3p suppresses granulosa cell migration and viability while promoting progesterone production in goose ovarian follicles by targeting ITGB8 and modulating ECM-related genes.

Identification of biological processes and signaling pathways for the knockout of REV-ERB in mouse brain

The paper identifies signaling pathways and biological processes affected by REV-ERB knockout in mouse brain using transcriptomic analysis.

Fragile X Mental Retardation Protein regulates R-loop formation and prevents global chromosome fragility

This study shows FMRP prevents chromosome fragility by reducing R-loop formation and identifies novel FXS-susceptible genes.

Childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic risk for depression

The paper examines how childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic depression risk in a genetically homogeneous population.

Microbial Cells Harboring a Mitochondrial Gene Are Capable of CO2 Capture

This study identifies a mitochondrial gene, OG1, capable of CO2 capture in engineered microorganisms, suggesting its potential for mitigating global warming through biological CO2 capture in barren lands.

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.

The reduced prevalence of macrolide resistance in Mycoplasma pneumoniae clinical isolates from pediatric patients in Beijing in 2016

The study reports macrolide resistance rates in Mycoplasma pneumoniae isolates from pediatric patients in Beijing, 2016, and identifies specific mutations associated with resistance.

Overlooked polyploidies in lycophytes generalize their roles during the evolution of vascular plants

The paper reanalyzes the genome of Selaginella moellendroffii and finds multiple polyploidies, suggesting they played a key role in the evolution of vascular plants.

Dynamic response to initial stage blindness in visual system development

The study investigates retinal development in infants with initial stage blindness, showing environmental influences on retinal malleability and its potential role in visual system plasticity.

A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years

This study estimates the timing of natural selection in the human genome over the past half-million years, identifying selection events related to brain evolution and Alzheimer's disease pathways.