Incorporation of single-neuron projectome-based connectivity motifs enhances the cortex-specific performance of artificial neural networks
Yue Sun, Wangzi Yao, Jian Zhang, W Song, Xuanle Zhao, Chonghe Hao, X S Chen, Shuxin Zeng, Shuncheng Jia, Yi Yang, Xiong Xiao, Mu‐ming Poo, Yangang Sun, Bo Xu, Tielin Zhang
This paper develops a connectome-informed neural network algorithm that improves RNN and LLM performance by incorporating natural cortical connectivity motifs.
bioRxiv · Jun 17, 2026 · PreprintNeuroscience