The interplay between biomechanics and cell kinetics explains the spatial pattern in liver fibrosis
Jieling Zhao, Seddik Hammad, Mathieu de Langlard, Pia Erdoesi, Yueni Li, Paul Van Liedekerke, Andreas Buttenschön, Manuel Winkler, Sina W. Kürschner, Philipp-Sebastian Reiners-Koch, Niels Grabe, Björn Hartleben, Stephanie D. Wolf, Johannes Georg Bode, Jan Georg Hengstler, , Dirk Drasdo
This paper develops a digital twin model to simulate liver fibrosis patterns, showing that ECM distribution results from cell death zones and biomechanical compression.
bioRxiv · Jul 31, 2025 · PreprintSystems Biology