Dirk Drasdo

This paper develops a digital twin model to simulate liver fibrosis patterns, showing that ECM distribution results from cell death zones and biomechanical compression.

This paper presents a community-driven benchmarking initiative for cell-based multiscale models, highlighting variations in tool implementations and advocating for standardized benchmarks and interoperability.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

The paper develops a 3D high-resolution cell-based model to study liver regeneration after drug-induced hepatocyte depletion, finding that migration forces required for tissue closure are lower than predicted by center-based models.

The paper develops an agent-based model to predict tumor spheroid growth under mechanical stress across different conditions and cell lines.