Integrative spatial profiling of 3D genome organization and gene expression in tissue
Pengfei Guo, Yan Cui, Jincan He, Abraham J. Waldman, Jiaxin Zhu, Yufan Chen, Zhi Huang, Jingtian Zhou, Jennifer E. Phillips‐Cremins, Yanxiang Deng
This paper introduces Spatial Hi-C-RNA, a spatial multi-omics technology that co-maps chromatin conformation and transcriptome in tissue, revealing spatially coherent domains and new insights into gene regulation.
Cell · Aug 25, 2026Peer-reviewedGenomics