Author
Yanxiang Deng
University of PennsylvaniaORCID 0000-0002-9975-8086Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2020-2026 · peak 5/yrCo-Author Collaboration Network
10 top collaborators · 37 mutual co-author links13 papers
Recent·Most cited
- BioengineeringbioRxivPreprint
Live Spatial Transcriptomics Enables Longitudinal Tissue Mapping
David E. Reynolds, Sangmo Lee, Chin Nien Lee…·Jina Ko
This paper introduces Live-ST, a method for longitudinal spatial transcriptomics, and demonstrates its use in tracking drug response in melanoma tissues.
DOI 10.64898/2026.10.28.761959 - GenomicsCellPeer-reviewed
Integrative spatial profiling of 3D genome organization and gene expression in tissue
Pengfei Guo, Yan Cui, Jincan He…·Yanxiang Deng
This paper introduces Spatial Hi-C-RNA, a spatial multi-omics technology that co-maps chromatin conformation and transcriptome in tissue, revealing spatially coherent domains and new insights into gene regulation.
- GenomicsbioRxivPreprint
Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues
Chin Nien Lee, Hongxiang Fu, Angelysia Cardilla…·Yanxiang Deng
This paper introduces a method for spatial co-profiling of DNA methylation and transcriptome in mammalian tissues, revealing spatial patterns and their interplay in development and brain function.
DOI 10.1101/2025.07.01.662607 - GeneticsNature MethodsPeer-reviewed
Multiplexed spatial mapping of chromatin features, transcriptome, and proteins in tissues
Pengfei Guo, Liran Mao, Yu‐Fan Chen…·Yanxiang Deng
The paper introduces spatial-Mux-seq, a multi-modal spatial technology that profiles five modalities in tissues, revealing new insights into cell types, gene regulation, and epigenetic gradients in mouse embryos and brains.
- GenomicsNaturePeer-reviewed
Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular level
Yanxiang Deng, Marek Bartošovič, Sai Ma…·Rong Fan
This paper introduces spatial-ATAC-seq, a method for spatially resolved chromatin accessibility profiling at the cellular level, and demonstrates its application in mouse embryos and human tonsil tissue.
- GenomicsSciencePeer-reviewed
Spatial Epigenome Sequencing at Tissue Scale and Cellular Level
Yanxiang Deng, Marek Bartošovič, Petra Kukanja…·Rong Fan
This paper presents spatial epigenome profiling using CUT&Tag and microfluidic barcoding to map histone modifications at tissue scale and single-cell level in mouse embryos and olfactory bulbs.
- GenomicsCellPeer-reviewed
High-Spatial-Resolution Multi-Omics Atlas Sequencing of Mouse Embryos via Deterministic Barcoding in Tissue
Yang Liu, Mingyu Yang, Yanxiang Deng…·Rong Fan
DBiT-seq enables high-spatial-resolution multi-omics mapping of mouse embryos by deterministic barcoding, revealing tissue types and fine features like retinal pigmented epithelium and microvasculature.
966 citationstop 1% - GenomicsbioRxivPreprint
Spatial transcriptome sequencing of FFPE tissues at cellular level
Yang Liu, Archibald Enninful, Yanxiang Deng, Rong Fan
The paper develops DBiT-seq for spatial transcriptome sequencing of FFPE tissues at the cellular level, demonstrating its application in mouse embryos and adult tissues.
26 citations