Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in Aldh2*2 knock-in mice
Yuki Takami, Jun Nakamura, Jun Katahira, Yuhei Maeda, Miyuu Tanaka, Mitsuru Kuwamura, Toshiya Okada, Takeshi Izawa
This study shows that Aldh2*2 knock-in mice exposed to allyl alcohol experience a systemic aldehyde storm leading to hepatic ferroptosis due to impaired aldehyde detoxification.
Free Radical Biology and Medicine · Jul 30, 2025Peer-reviewedPathology