IF1 restrains excessive elevation of the mitochondrial membrane potential and safeguards the epithelial state of human iPSCs
Kaoru Kinjo, Gakuya Takamatsu, Kanako Toyama, Chitoshi Takayama, Yuko Akamine, Riko Kuniyoshi, Naoaki Otsuka, Yoko Manome, Hirotaka James Okano, Chiaki Katagiri, Mitsuyoshi Takatori, Masayuki Matsushita
This study shows that IF1 limits mitochondrial membrane potential elevation and prevents epithelial-mesenchymal transition in human iPSCs by inhibiting ATP hydrolysis.
bioRxiv · Sep 3, 2026 · PreprintCell Biology