Synergistic Inhibition of Notch Signaling and Forced Cell Cycle Re-entry Drive Müller Glia Reprogramming in Uninjured Mouse Retina
Baoshan Liao, Chengshang Lyu, Yuqing Jiang, S. H. Liu, Waiho Wong, Jiadong Zhang, Hoyin Tsang, Junxi Xie, L L Chen, Qinrong Zhang, Wenjun Xiong
This study shows that inhibiting Notch signaling and forcing cell cycle re-entry in Müller glia promotes their reprogramming into neurons in uninjured mouse retina.
bioRxiv · Jul 8, 2026Cell Biology