Quantitative Modeling of TLR Signaling Reveals Missing Negative Feedback Guiding Identification of TANK-IKKε Checkpoint
Nathan P. Manes, Fengkai Zhang, Bin Lin, Jing Sun, Sergio A. Hassan, Anthony A. Armstrong, Yuting Shao, Jessica M. Calzola, Pauline R. Kaplan-Stafford, Rachel A. Gottschalk, Matthew J. Marino, Doeun Kim, Ronald N. Germain, Martin Meier‐Schellersheim, Iain D. C. Fraser, Aleksandra Nita‐Lazar
The paper develops a rule-based model of TLR4 signaling in mouse macrophages, identifies a missing negative feedback checkpoint involving TANK and IKKε, and validates its role in restraining inflammation.
bioRxiv · Aug 19, 2026 · PreprintSystems Biology