Ronald N. Germain

The paper develops a rule-based model of TLR4 signaling in mouse macrophages, identifies a missing negative feedback checkpoint involving TANK and IKKε, and validates its role in restraining inflammation.

This study identifies PD-1's role in maintaining stem-like CD8+ T cells through TCR affinity regulation and signaling fine-tuning, showing its impact on immunotherapy efficacy.

The paper shows that balancing viral damage, immune response, and tissue repair can prevent death from lethal influenza by combining antiviral drugs with strategies to enhance epithelial repair.

This study identifies the Bhlhe40-Pou2af1 axis as a transcriptional regulator of CXCR5 expression in Tfh cells, independent of the Bcl6-Blimp1 pathway.

This study identifies immune-tumor interactions that drive tumor dormancy in a mouse model, highlighting IFN-γ-KLF4-SLURP1 and CD200-CD200R1 pathways.

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

SPACE identifies complex spatial patterns in high-plex spatial data by analyzing ensembles of tissue elements across multiple datasets.

A small increase in NOD1 expression leads to cancer-promoting changes in cell state by promoting persistent inflammation and oncogene expression.