2-hydroxyglutarate controls centromere and heterochromatin conformation and function in the male germline
N. Mayorek, M. Schlossberg, Y. Mansour, N. Pillar, I. Stein, F. Mushasha, G. Baziza, E. Medvedev, Z. Manevitch, J. Menzel, E. Aizenshtein, B. Sarvin, N. Sarvin, T. Shlomi, M. Klutstein, E. Pikarsky
This study shows that L-2HG, produced by LDHC in spermatogenesis, regulates centromere and heterochromatin structure and function in the male germline.
bioRxiv · May 29, 2022 · PreprintCell Biology