Expression of mini-G proteins specifically halt cognate GPCR trafficking and intracellular signalling
Y. Manchanda, Z. Ramchunder, M. M. Shchepinova, G. A. Rutter, A. Inoue, E. W. Tate, B. Jones, A. Tomas
This paper shows that mini-G proteins block GPCR trafficking and signaling by preventing receptor internalization, and proposes a nanobody-based alternative assay.
bioRxiv · Nov 24, 2021 · PreprintCell Biology