Author

Y. Manchanda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:mouse· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Tomas· 4 shared B. Jones· 4 shared A. Inoue· 2 shared G. A. Rutter· 2 shared S. Bitsi· 2 shared B. Hansen· 1 shared D. Carling· 1 shared E. R. McGlone· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

A. Tomas

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4 papers

Recent·Most cited

An examination of the divergent spatiotemporal signaling of GLP-1R versus GIPR in pancreatic beta cells

Y. Manchanda, S. Bitsi, S. Chen, J. Broichhagen, J. Bernardino de la Serna, B. Jones, A. Tomas

This study compares the trafficking and signaling of GLP-1R and GIPR in pancreatic beta cells, revealing differences in internalization, recycling, and subcellular activity.

bioRxiv · Aug 17, 2022 · PreprintCell Biology

Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice

S. Bitsi, Y. Manchanda, L. ElEid, N. Mohamed, B. Hansen, K. Suba, G. A. Rutter, V. Salem, B. Jones, A. Tomas

This study examines GLP-1R responses in beta cell-specific β-arrestin 2 knockout mice, finding acute deficits and prolonged effects with certain agonists.

bioRxiv · Apr 21, 2022 · PreprintCell Biology

Expression of mini-G proteins specifically halt cognate GPCR trafficking and intracellular signalling

Y. Manchanda, Z. Ramchunder, M. M. Shchepinova, G. A. Rutter, A. Inoue, E. W. Tate, B. Jones, A. Tomas

This paper shows that mini-G proteins block GPCR trafficking and signaling by preventing receptor internalization, and proposes a nanobody-based alternative assay.

bioRxiv · Nov 24, 2021 · PreprintCell Biology

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

E. R. McGlone, Y. Manchanda, B. Jones, P. Pickford, A. Inoue, D. Carling, S. R. Bloom, T. M. Tan, A. Tomas

This study investigates how RAMP2 affects GCGR trafficking and signaling in hepatocytes, showing it alters receptor internalization and signaling bias with limited metabolic impact.

bioRxiv · May 9, 2021Cell Biology