B. Jones

Single-molecule spatial genomics reveals the multi-scale organization and plasticity of extrachromosomal DNA in glioblastoma

This study uses single-molecule spatial genomics to show how extrachromosomal DNA is organized and regulated in glioblastoma, linking it to tumor heterogeneity and microenvironmental influences.

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

This study identifies and validates cholesterol binding sites on GLP-1R in pancreatic beta cells, showing their role in receptor function and potential for drug design.

Spatial transcriptomics identifies novel Pseudomonas aeruginosa virulence factors

This study uses spatial transcriptomics to identify novel Pseudomonas aeruginosa virulence factors and host-pathogen interactions in ocular infection.

A type II secreted subtilase from commensal rhizobacteria disarms the immune elicitor peptide flg22

The paper identifies a type II secreted subtilase from commensal bacteria that cleaves the immune elicitor flg22, suppressing plant immune responses.

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

Microfluidic platform enables shear-less aerosolization of lipid nanoparticles for messenger RNA inhalation

This paper introduces a microfluidic platform for aerosolizing lipid nanoparticles without shear forces, improving mRNA delivery efficiency and safety in respiratory applications.

Adventitial macrophage accumulation impairs perivascular nerve function in mesenteric arteries with inflammatory bowel disease

This study shows that adventitial macrophage accumulation in mesenteric arteries with IBD impairs perivascular nerve function, particularly sensory vasodilation, which is reversed by macrophage depletion.

Control of human pancreatic beta cell kinome by GLP-1R biased agonism

This study compares kinase activity profiles in human pancreatic beta cells stimulated by GLP-1R agonists with different bias, revealing distinct kinomic responses and potential therapeutic targets.

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis

This study shows that loss of intra-islet glucagon receptor signaling impairs glucose tolerance and insulin pulsatility in mice, suggesting glucagonergic agents could restore insulin pulsatility in T2D.

An examination of the divergent spatiotemporal signaling of GLP-1R versus GIPR in pancreatic beta cells

This study compares the trafficking and signaling of GLP-1R and GIPR in pancreatic beta cells, revealing differences in internalization, recycling, and subcellular activity.

Genetic characterisation of the Theileria annulata cytochrome b locus and its impact on buparvaquone resistance in ruminants

This study identifies mutations in the cytochrome b locus of Theileria annulata associated with buparvaquone resistance and shows evidence of positive selection and haplotype spread in buffalo and cattle isolates.

Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice

This study examines GLP-1R responses in beta cell-specific β-arrestin 2 knockout mice, finding acute deficits and prolonged effects with certain agonists.

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

Expression of mini-G proteins specifically halt cognate GPCR trafficking and intracellular signalling

This paper shows that mini-G proteins block GPCR trafficking and signaling by preventing receptor internalization, and proposes a nanobody-based alternative assay.

Hepatocyte cholesterol content modulates glucagon receptor signalling

This study shows that hepatocyte cholesterol content affects glucagon receptor signaling, with higher cholesterol reducing glucagon's ability to lower blood sugar in NAFLD.

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

This study investigates how RAMP2 affects GCGR trafficking and signaling in hepatocytes, showing it alters receptor internalization and signaling bias with limited metabolic impact.

Diaphragm muscle fibrosis involves changes in collagen organization with mechanical implications in Duchenne Muscular Dystrophy

This study examines collagen organization changes in diaphragm muscle of DMD mice, showing increased fiber straightness and stiffness with disease progression.

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

This study compares the efficacy and affinity of two GLP-1R agonists, P5 and exendin-F1, showing that exendin-F1's lower acute efficacy correlates with sustained insulin secretion and anti-hyperglycaemic effects.

Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking

This study compares exendin-4 and its acylated variant exendin-4-C16, showing acylation affects GLP-1R signaling bias, trafficking, and pharmacokinetics.

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

The anthropometric and physical qualities of womens rugby league Super League and international players; identifying differences in playing position and standard

This study quantifies anthropometric and physical qualities of women's rugby league players, finding differences between playing positions and standards.

Sulfonated rhodamines as impermeable labelling substrates for cell surface protein visualization

The paper introduces sulfonated rhodamines as impermeable dyes for cell surface protein labeling, validated in live cell imaging and STED nanoscopy.

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

This study shows that partial agonism of GLP-1R/GCGR co-agonists improves anti-hyperglycaemic efficacy by reducing β-arrestin-2 recruitment, leading to prolonged glucose-lowering effects and comparable weight loss to liraglutide.

Selective BCL-XLAntagonists Eliminate Infected Cells from a Primary Cell Model of HIV Latency but not from Ex Vivo Reservoirs

This study shows BCL-XL antagonists reduce HIV in a cell model of latency but not in ex vivo reservoirs, suggesting resistance in true reservoir cells.

Scanning ion conductance microscopy reveals differences in the ionic environments of gram positive and negative bacteria

This paper uses scanning ion conductance microscopy to compare the ionic environments of gram-positive and gram-negative bacteria, finding significant differences in surface charge and conductivity.

Deuterated rhodamines for protein labelling in nanoscopy

This paper introduces deuterated rhodamines for improved fluorescence microscopy applications, showing enhanced photophysical and chemical properties.

Multidecadal decline and recovery of aspen experiencing contrasting fire regimes: long-unburned, infrequent and frequent mixed-severity wildfire

This study examines how aspen stands respond to different fire regimes over time, finding that fire promotes aspen recovery by reducing conifer competition, while fire exclusion leads to decline.

Signal bias at glucagon family receptors: rationale and downstream impacts

The paper investigates signal bias at glucagon family receptors, showing biased agonists affect intracellular signaling and insulin secretion differently.