INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA
S. Sukhanov, Y. Higashi, T. Yoshida, S. Danchuk, M. Alfortish, T. Goodchild, A. Scarborough, T. Sharp, J. S. Jenkins, D. Garcia, J. Ivey, D. L. Tharp, J. Schumacher, Z. Rozenbaum, J. K. Kolls, , P. Delafontaine
This study shows that IGF-1 reduces coronary atherosclerosis and promotes stable plaque features in FH pigs, with spatial transcriptomics revealing potential mechanistic insights.
bioRxiv · Sep 23, 2022Cell Biology