Cell BiologybioRxiv
INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA
S. Sukhanov, Y. Higashi, T. Yoshida…·P. Delafontaine
This study shows that IGF-1 reduces coronary atherosclerosis and promotes stable plaque features in FH pigs, with spatial transcriptomics revealing potential mechanistic insights.
DOI 10.1172/jci.insight.165713