C1orf109L promote R-loop accumulation induced DNA damage to inhibit cell growth
L. Yu, H. Fang, D. Peng, L. Yiqun, X. Wanqiu, Z. Xiaoqing, Z. Dandan, C. Yanpeng, Q. Shupei, Z. Xiaohan, M. Luqman Akhtar
The paper shows C1orf109L promotes R-loop accumulation, causing DNA damage and cell cycle arrest, which inhibits cell growth and may be a target for cancer therapy.
bioRxiv · May 2, 2019 · PreprintCell Biology