D. Peng

Hormonal dynamics reveal a stimulatory role for secretoneurin in zebrafish ovulation

This study shows that secretoneurin stimulates ovulation in zebrafish by increasing gene expression in the hypothalamic-pituitary-ovarian axis and inducing ovulation in anovulatory females.

Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

This study shows DFMO inhibits Ewing sarcoma metastasis by inducing ferroptosis through polyamine depletion.

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

The paper maps subcellular localization of human proteins and shows proteome remodeling during viral infection by combining organelle immuno-capture with mass spectrometry.

S2' cleavage site plays a decisive role in expansion of Vero cell tropism by infectious bronchitis virus HV80, with Q855H promoting cell-to-cell fusion

This study identifies the S2' cleavage site and Q855H mutation as critical for HV80's Vero cell tropism and cell-to-cell fusion.

SOGO-SOFI, light-modulated super-resolution optical fluctuation imaging using only 20 raw frames for high-fidelity reconstruction

This paper introduces SOGO-SOFI, a light-modulated super-resolution imaging technique that uses only 20 frames for high-fidelity reconstruction, achieving higher temporal resolution and reduced artifacts compared to pcSOFI.

Improved fluorescent proteins for dual-color post-embedding CLEM

The paper develops improved fluorescent proteins for dual-color post-embedding CLEM, enhancing signal-to-background ratio and reducing autofluorescence background.

Previously unrecognized non-reproducible antibody-antigen interactions and their implications for diagnosis of viral infections including COVID-19

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

Mitochondria surveillance systems trigger innate immune responses to bacterial pathogens via AMPK pathway in C. elegans

This study shows that C. elegans uses mitochondrial surveillance systems and the AMPK pathway to trigger innate immune responses against bacterial pathogens through non-PRR patterns.

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

This study uses long-read sequencing and proximity ligation mapping to analyze genetic diversity in two T. cruzi strains, revealing mechanisms of gene amplification, dispersion, and recombination that contribute to immune evasion and genome evolution.

SHP2 Inhibition Abrogates Adaptive Resistance to KRASG12C-Inhibition and Remodels the Tumor Microenvironment of KRAS-Mutant Tumors

This study shows that combining SHP2 inhibitors with KRASG12C inhibitors enhances efficacy in PDAC and NSCLC by overcoming resistance and remodeling the tumor microenvironment.

C1orf109L promote R-loop accumulation induced DNA damage to inhibit cell growth

The paper shows C1orf109L promotes R-loop accumulation, causing DNA damage and cell cycle arrest, which inhibits cell growth and may be a target for cancer therapy.

Bacillus thuringiensis targets the host intestinal epithelial junctions for successful infection of Caenorhabditis elegans

This paper shows Bacillus thuringiensis uses Cry toxins and PlcR-regulated virulence factors to disrupt C. elegans intestinal epithelial junctions, enabling successful infection.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.