H. Fang

SlNAP2 promoted fruit ripening by directly binding the ACS2 promoter and interacting with EIL3

This study identifies SlNAP2 as a NAC transcription factor that promotes tomato fruit ripening by directly binding the ACS2 promoter and interacting with EIL3 to enhance ethylene signaling.

Multi-omics discovery of hallmark protein and lipid features of circulating small extracellular vesicles in humans

The paper identifies hallmark protein and lipid features of circulating extracellular vesicles in humans using multi-omics analysis and provides an open-source tool for further exploration.

Fertilization-induced synergid cell death by RALF12-triggered ROS production and ethylene signaling

This study identifies RALF12-triggered ROS production and ethylene signaling as mechanisms causing synergid cell death during fertilization in maize.

Atlas of Fshr Expression from Novel Reporter Mice

This paper develops Fshr-ZsGreen knockin reporter mice to study FSHR expression in vivo, revealing novel extragonadal expression patterns and expanding the known physiological roles of the FSH-FSHR pathway.

Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor

This paper identifies a new mechanism by which NPRC inhibits NP signaling by forming heterodimers with NPRA or NPRB, preventing cGMP production.

Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

This study shows that reducing SURF4 in the liver decreases PCSK9 and increases LDLR, leading to lower plasma cholesterol despite reduced lipoprotein secretion.

Evolution of inflammation and immunity in a dengue virus 1 human infection model

This study analyzes the immune and virologic responses in humans infected with DENV-1, revealing new insights into the kinetics and composition of immune responses and gene modules involved in DENV infection.

Monomeric IgA antagonizes IgG-mediated enhancement of DENV infection

This study shows that monomeric IgA can neutralize DENV and block IgG-mediated antibody-dependent enhancement (ADE) in vitro.

Variable Induction of Pro-inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo

This study shows that commercial SARS CoV-2 spike protein reagents vary in their ability to induce pro-inflammatory cytokines, likely due to contamination with endotoxin (LPS).

Genome recombination-mediated tRNA up-regulation conducts general antibiotic resistance of bacteria at early stage

The paper shows that bacterial DNA recombination increases tRNA levels early in antibiotic stress, aiding resistance before efflux pumps or mutations.

High-throughput tandem-microwell assay for ammonia repositions FDA-Approved drugs to Helicobacter pylori infection

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

C1orf109L promote R-loop accumulation induced DNA damage to inhibit cell growth

The paper shows C1orf109L promotes R-loop accumulation, causing DNA damage and cell cycle arrest, which inhibits cell growth and may be a target for cancer therapy.

Transcriptome Analysis of juvenile Pacific White Shrimp (Litopenaeus vannamei) with symptom of stunted growth

This study identifies virus-related genes associated with stunted growth in juvenile Pacific White Shrimp through transcriptome analysis.

Exploring the influence of surface proteins on probiotic activity of Lactobacillus pentosus HC-2 in Litopenaeus vannamei midgut via Label-free quantitative proteomic analysis

This study identifies surface proteins of Lactobacillus pentosus HC-2 as essential for its probiotic effects in shrimp midgut using proteomic analysis.

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

This study identifies WDR45's role in neurodegeneration by showing its regulation of ER homeostasis and neuronal death through autophagy defects.

Persistent homology demarcates a leaf morphospace

This paper uses persistent homology to analyze leaf shapes from 182,707 leaves across 141 plant families, revealing phylogenetic and geographic differences in leaf morphology.