Author

Zekun Guo

Beijing Academy of Artificial IntelligencePrimary ORCID profile (0000-0003-3872-7881 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Zekun GuoiD1 paper · Northwest A&F University

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Research Focus:protein design· 1

Frequent Co-Authors

Peiran Jin· 3 shared Fusong JuiD· 2 shared Haiguang LiuiD· 2 shared Huanhuan XiaiD· 2 shared Jiaying Xu· 2 shared Pan DengiD· 2 shared Tao Qin· 2 shared Chang LiuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersGenomics

Peiran Jin

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3 papers

Recent·Most cited

RegDesign-Bench: Benchmarking computational methods for cell-type-specific regulatory DNA design

Jiaying Xu, Zekun Guo, Cuiting Zhong, Qijin Yin, Yuan He, Zeyu Chen, Hongyi Xin, Peiran Jin, Pan Deng

RegDesign-Bench evaluates computational methods for designing cell-type-specific regulatory DNA, showing that performance on individual metrics does not guarantee overall effectiveness.

bioRxiv · Oct 19, 2026 · PreprintGenomics

Phenotype-Guided In Silico Molecular Generation Using Large Language Models

Qun Jiang, Xing Ye, Zekun Guo, Yingce Xia, Zequn Liu, Jiaying Xu, Peiran Jin, Fusong Ju, Huanhuan Xia, Shangya Feng, Rui Jiang, Haiguang Liu, Tao Qin, Pan Deng, Sida Shao

GEMGen generates small molecules from transcriptomic data to phenocopy gene knockdown effects and identify novel inhibitors.

bioRxiv · Jan 5, 2026 · PreprintCell Biology

FlexRibbon: Joint Sequence and Structure Pretraining for Protein Modeling

Jianwei Zhu, Yu Shi, Ran Bi, Peiran Jin, Chang Liu, Zhenyu Zhang, Haitao Huang, Zekun Guo, Pipi Hu, Fusong Ju, Lin Huang, Xinwei Tai, Chenao Li, Kaiyuan Gao, Xinran Wei, , Tao Qin

FlexRibbon is a pretrained protein model that jointly learns from sequences and structures, achieving state-of-the-art performance in mutation-rich settings.

bioRxiv · Oct 8, 2025 · PreprintMolecular Biology