Phenotype-Guided In Silico Molecular Generation Using Large Language Models
Qun Jiang, Xing Ye, Zekun Guo…·Sida Shao
GEMGen generates small molecules from transcriptomic data to phenocopy gene knockdown effects and identify novel inhibitors.
Author
Beijing Academy of Artificial IntelligenceORCID 0000-0002-4699-1853Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Qun Jiang, Xing Ye, Zekun Guo…·Sida Shao
GEMGen generates small molecules from transcriptomic data to phenocopy gene knockdown effects and identify novel inhibitors.
Jianwei Zhu, Yu Shi, Ran Bi…·Tao Qin
FlexRibbon is a pretrained protein model that jointly learns from sequences and structures, achieving state-of-the-art performance in mutation-rich settings.
Tianze Wang, Yan Pan, Fusong Ju…·Pan Deng
CellNavi predicts driver genes for cell state transitions using a deep learning framework that integrates gene graphs with transcriptomics data across diverse cell types and perturbations.
Yongge Li, Fusong Ju, Zhiyuan Chen…·Pan Deng
CREaTor models cis-regulatory patterns using attention mechanisms and RNA-seq/ChIP-seq data, outperforming existing methods in predicting cCRE-gene interactions across cell types.