A lactate-HIF1-VDR positive feedback loop drives protective SPP1+ macrophage differentiation to inhibit schistosomiasis induced liver fibrosis
Zhou Xing, Pingping Yang, Huiyu Xia, Rui Yin, Bin Le, Fangbin Zhou, Xiaoying Guo, Xiaobin Fan, Xing He
This study identifies a lactate-HIF1alpha-VDR-SPP1 feedback loop that promotes protective macrophage differentiation to reduce liver fibrosis in schistosomiasis.
bioRxiv · Sep 21, 2026 · PreprintImmunology