Author

Xing He

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

Bin Le· 1 shared Chenqi XuiD· 1 shared Chenxi Li· 1 shared Fangbin Zhou· 1 shared Guangyu LuiD· 1 shared Hao Qian· 1 shared Huiyu XiaiD· 1 shared Jing Huang· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

Bin Le

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3 papers

Recent·Most cited

A lactate-HIF1-VDR positive feedback loop drives protective SPP1+ macrophage differentiation to inhibit schistosomiasis induced liver fibrosis

Zhou Xing, Pingping Yang, Huiyu Xia, Rui Yin, Bin Le, Fangbin Zhou, Xiaoying Guo, Xiaobin Fan, Xing He

This study identifies a lactate-HIF1alpha-VDR-SPP1 feedback loop that promotes protective macrophage differentiation to reduce liver fibrosis in schistosomiasis.

bioRxiv · Sep 21, 2026 · PreprintImmunology

Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness

Yanchi Li, Xing He, Chenxi Li, Zhengxu Ren, Jing Huang, Qian Yang, Mingming Gao, Yingjie Wu, Xiwei Liu, Chenqi Xu

This study identifies OSBP as essential for ER-to-PM cholesterol transport in T cells, linking cholesterol spatial distribution to TCR signaling and T-cell development.

bioRxiv · Aug 20, 2026 · PreprintImmunology

SOX8-USP7-PGC-1α axis enhances thermogenesis in brown adipocytes

Yuqin Gu, Ziheng Kan, Guangyu Lu, Yongcong Cai, Xingjing Yang, qi zhu, Y Li, Xing He, Xue Yang, Zhenglin Yang, Hao Qian, Ziyan Wang

This study identifies a SOX8-USP7-PGC-1α regulatory axis in brown adipocytes that enhances thermogenesis but also causes metabolic maladaptation with prolonged activation.

bioRxiv · May 27, 2026 · PreprintCell Biology