Zihao Chen

Agentic transcranial functional ultrasound imaging: @fUS

The paper introduces @fUS, an agentic transcranial fUS imaging platform that enables functional brain imaging in mice with high spatial and temporal resolution, supporting longitudinal studies without surgery.

Characterizing the Spatiotemporal Boundaries of Functional Ultrasound for Brain Decoding

This study characterizes the spatiotemporal response properties of fUS-CBV signals in mice during whisker stimulation, showing they retain structured information for reliable decoding.

Ventricular Expansion Couples Hyperosmotic Stress to Thirst

The paper shows that ventricular expansion in mice links hyperosmotic stress to thirst by mechanically activating candidate mechanosensitive channels.

Evolutionarily conserved neural dynamics across mice, monkeys, and humans

The paper shows that neural dynamics during movement are conserved across mice, monkeys, and humans, despite phylogenetic differences.

Toward Computationally Complete Spatial Omics

COSIE is a computational framework that integrates multiple spatial omics modalities to generate high-resolution molecular landscapes, outperforming existing methods across diverse datasets.

Multiscale confidence quantification for virtual spatial transcriptomics with UTOPIA

UTOPIA quantifies confidence in virtual spatial transcriptomics predictions across scales, improving reliability and preventing false conclusions.

Reconstructing multi-scale tissue spatial architecture from single-cell RNA-seq with REMAP

REMAP reconstructs spatial tissue architecture from scRNA-seq using deep learning and ST references, revealing microenvironmental features and cancer subtypes.