Author

Le Sun

Capital Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Neuroscience· 3 Bioengineering· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Aline Maria Araújo MartinsiD· 1 shared Blake L. TsuiD· 1 shared Bo LiiD· 1 shared Boxing LiiD· 1 shared Changmei ZhangiD· 1 shared Chen Yang· 1 shared Christopher A. BarnesiD· 1 shared Chunyu LiuiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperNeuroscience

Aline Maria Araújo MartinsORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Agentic transcranial functional ultrasound imaging: @fUS

Zihao CHEN, Zexin Yuan, Zhaoqi Lu, Na Li, 符策奕, Le Sun, Hongying Yao, Huizhu Liu, Quanxiang Xian, Tianyi Wang, Wei Li, Zirui Liang, Boxing Li, Ying Zhang, Ying Li, , Zhihai Qiu

The paper introduces @fUS, an agentic transcranial fUS imaging platform that enables functional brain imaging in mice with high spatial and temporal resolution, supporting longitudinal studies without surgery.

bioRxiv · Sep 28, 2026 · PreprintBioengineering

Modeling Meibomian Gland Development and Dysfunction: A Mouse-Derived Organoid System Reveals Hippo-YAP as a Critical Regulator

Meiqin Zhong, Jingbin Zhuang, Lingyu Zhang, Rongrong Zhang, Le Sun, Wenhua Li, Yang Wu, Jinghua Bu

This study develops a mouse-derived organoid model of meibomian glands and identifies the Hippo-YAP pathway as critical for gland development and dysfunction.

bioRxiv · May 15, 2026 · PreprintDevelopmental Biology

Patch-Clamp Single-Cell Proteomics in Acute Brain Slices: A Framework for Recording, Retrieval, and Interpretation

Larry Rodriguez, Jolene K. Diedrich, Le Sun, Blake L. Tsu, Stefanie N. Kairs, Roman Vlkolinský, Christopher A. Barnes, Aline Maria Araújo Martins, Marisa Roberto, John R. Yates

This paper introduces a framework for interpreting single-cell proteomics data from patch-clamped neurons in acute brain slices, showing how retrieval quality affects proteomic outcomes.

bioRxiv · Sep 15, 2025 · PreprintNeuroscience

Multiple-level organizational logic of the locus coeruleus-norepinephrine system in structure and function

Changmei Zhang, Yongxin Yang, Fu-Ning Li, Hui Zhang, Le Sun, Jia Li, Chen Yang, Zhi-Feng Yue, Jiesi Feng, Yulong Li, Rongwei Zhang, Jie He, Xu-Fei Du, Jiulin Du

The paper reveals how locus coeruleus-norepinephrine neurons organize to regulate brain-wide neural dynamics through region-specific axon projections and synchronized firing.

bioRxiv · Jun 11, 2025 · PreprintNeuroscience

Attenuating amyloid-beta pathology in mice with in situ programmed astrocytes

Lun Zhang, Shuai Lü, Yingbo Jia, Shengjie Hou, Jie Zhu, Xiaoge Liu, Xiaoying Sun, Yaru Huang, Yu-xuan Zhao, Hongan Ren, Chunyu Liu, Fang Cui, Dong‐qun Liu, Xiao-yu Du, Xiao-yun Niu, , Rui‐tian Liu

This study introduces CAR-engineered astrocytes to target Aβ oligomers in Alzheimer's disease, showing improved phagocytosis and reduced inflammation in mice.

bioRxiv · Oct 30, 2023 · PreprintNeuroscience