Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognition
Morgan E. Abernathy, William B. Foreman, Jasmyn A Lopez, Viren A. Baharani, Danielle Vahdat, Yu Erica Lee, Michael R. Eso, zijun wang, Paul D. Bieniasz, Michel C. Nussenzweig, Tyler N. Starr, Christopher O. Barnes
This study identifies two antibodies that recognize conserved SARS-CoV-2 RBD epitopes, revealing structural mechanisms for broad neutralization and escape pathways.
bioRxiv · Aug 21, 2026 · PreprintBiophysics