Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through Olig1/2 during Mammalian Cortical Gliogenesis and Gliomagenesis
Yu Tian, Ziwu Wang, Feihong Yang, Wen Zhang, Jialin Li, Lin Yang, Tao Fu, Wenhui Zheng, Zhejun Xu, Tong Ma, Yan You, Xiaosu Li, Jiangang Song, Yunli Xie, Zhengang Yang, Zhuangzhi Zhang
This study shows that Olig1/2 knockout in gliogenesis shifts glial precursor cells to produce non-proliferative interneurons instead of oligodendrocyte precursors, and identifies dorsal cortical GPCs as origin of H3.3G34R/V-mutant tumors.
Nature Communications · Nov 5, 2025Peer-reviewedNeuroscience