Circadian feeding rhythm loss drives sex-specific β-cell dysfunction in diet-induced obesity
Luhui Zhang, Satish K Sen, Kuntol Rakshit, Thanh Nguyen, Kazuno Omori, Ananya Bharath, Zong Wei, Alexandre Gaspar-Maia, Aleksey V Matveyenko
This study shows that diet-induced obesity disrupts circadian β-cell function more in male mice than females, with time-restricted feeding partially restoring these effects.
bioRxiv · Nov 3, 2026 · PreprintPhysiology