Author

Robert P. Sparks

Northeastern UniversityORCID 0000-0002-0485-8317Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alan C. MulleniD· 1 shared Aliasgar TopiwallaiD· 1 shared Amel Ben SaadiD· 1 shared Charlie T. KnappiD· 1 shared Chi ZhangiD· 1 shared Daniel GrudzieniD· 1 shared Emad TajkhorshidiD· 1 shared Iftikhar AhmadiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Alan C. MullenORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Yeast PI(3,4,5)P3 controls vacuole fusion through Vam7 and membrane microdomain assembly

Chi Zhang, Jorge D. Calderin, Vito Failla, Aliasgar Topiwalla, Robert P. Sparks, Daniel Grudzien, Soroush Asadi, Lylia Gomez, Yupeng Li, Ved Shah, Krish T Patel, Jahnavi M. Karat, Charlie T. Knapp, Razeen Ahmed, Emad Tajkhorshid, Rutilio A. Fratti

This study identifies PI(3,4,5)P3 as a regulator of yeast vacuole fusion, showing it controls vertex microdomain assembly and retains the SNARE Vam7 on membranes.

The Journal of Cell Biology · Oct 30, 2026Peer-reviewedBiochemistry

Singletrome: A method to analyze and enhance the transcriptome with long noncoding RNAs for single cell analysis

Raza‐Ur Rahman, Iftikhar Ahmad, Zixiu Li, Robert P. Sparks, Amel Ben Saad, Alan C. Mullen

Singletrome enhances scRNA-seq analysis by integrating lncRNA annotations, improving mapping specificity and enabling lncRNA-based cell type clustering and disease prediction.

Scientific Reports · Aug 12, 2025Peer-reviewedBioinformatics