Emad Tajkhorshid

This study identifies a high-order ion-coupling mechanism in EAAT transporters by showing that dEAAT2 can acquire Na+, H+, and K+ dependence through mutations, mimicking human hEAAT2's complex ion coupling.

This study identifies PI(3,4,5)P3 as a regulator of yeast vacuole fusion, showing it controls vertex microdomain assembly and retains the SNARE Vam7 on membranes.

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

This study examines how stereochemistry affects electron transport in peptides through experiments and simulations, showing that stereochemical modifications alter conductance via aromatic interactions or secondary structure effects.

The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.

This paper shows that effector proteins are mechanically labile, unfolding from the N-terminus, which facilitates their secretion via the Type III secretion system.

This study shows that antibodies against influenza virus neutralize by interacting with the viral membrane, and disrupting these interactions reduces their effectiveness.

This study uses cryo-EM and molecular dynamics to analyze conformational transitions in AE1 and shows how PIP2 lipids inhibit transport by stabilizing the outward-facing state.

The paper identifies intermediate voltage-sensor conformations in hERG channels caused by LQTS-associated mutations using FLIM, tmFRET, and MD simulations.

The paper determines the structure of E. coli LetAB, identifies LetA as a novel transporter family, and proposes a mechanism for lipid transport using proton-motive force.

This study reveals how lipid competition modulates drug affinity in ABC exporters through structural and simulation analyses of BmrCD.

The paper introduces xMAS Builder, a tool that constructs atomistic membrane models for MD simulations using experimental data, and demonstrates its ability to generate stable models with insights into membrane packing density.

The paper uses single-molecule imaging to show how RNase E's membrane-binding motif and C-terminal domain affect its localization, diffusion, and mRNA degradation in E. coli.

This study investigates how secondary structure influences electron transport in peptides using a combination of experiments and computational methods, revealing a two-state conductance behavior linked to conformational flexibility.

This study identifies key regions and binding modes of beta-2-glycoprotein I domain V interacting with anionic membranes, important for antiphospholipid syndrome pathogenesis.

The paper introduces a topological learning method to predict lipid effective temperatures from static coordinates using persistent homology and machine learning.

This study determines the atomic structure of alpha-synuclein fibrils from Lewy body dementia tissue using a novel amplification method and solid-state NMR.

This paper isolates and characterizes the serotonin transporter (SERT) from porcine brain, revealing its monomeric state and structural interactions with psychostimulants like methamphetamine and cocaine.

This paper develops a whole-cell computational model of HBV infection and drug interactions to predict infection pathways and optimal drug dosing.

The paper investigates how mutations in SLC1A3 (hEAAT1) affect chloride channel activity and glutamate transport in glial cells, linking these changes to the pathology of episodic ataxia type 6.

This study investigates the molecular mechanisms of partial agonist action and conformational transitions in the glycine receptor using electrophysiology, MD simulations, and cryo-EM.

This study identifies overexpression of a non-muscle RBFOX2 isoform as a cause of cardiac conduction defects in myotonic dystrophy by inducing arrhythmia and altering ion channel splicing.