Amel Ben Saad

This study models the MTARC1 A165T variant in human liver organoids, showing reduced steatosis, inflammation, and fibrosis compared to reference sequence organoids.

Singletrome enhances scRNA-seq analysis by integrating lncRNA annotations, improving mapping specificity and enabling lncRNA-based cell type clustering and disease prediction.

This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.

The paper evaluates three NAFLD liver organoid models using single-cell transcriptomics, finding TGF-β1 induces fibrosis while OA reduces fibrotic signatures.