Hyaluronidase impacts exposures of long-acting injectable paliperidone palmitate in rodent models
Henry E. Pertinez, Amit Kaushik, Paul Curley, Usman Arshad, Eman El‐Khateeb, Si‐Yang Li, Rokeya Tasneen, Joanne Sharp, Edyta Kijak, Joanne Herriott, Megan Neary, Michaël Noë, Charles W. Flexner, Eric L. Nuermberger, Andrew Owen, Nicole C. Ammerman
This study evaluates how hyaluronidase affects the release and pharmacokinetics of a long-acting injectable drug in mice and rats.
bioRxiv · Mar 3, 2024 · PreprintPharmacology & Toxicology