Laurent Modolo

Magnetic organelle gene clusters enable bacterial growth and ATP homeostasis under oxidizing conditions

This study shows that gene clusters for magnetite formation in bacteria confer resistance to hydrogen peroxide, supporting an early origin of magnetotactic bacteria before Earth's oxygenation.

Trans-acting mutations reveal non-nuclear modulators of both intrinsic and extrinsic gene expression noise in a eukaryote.

The paper identifies trans-acting mutations in yeast that modulate gene expression noise in both intrinsic and extrinsic ways, revealing non-nuclear factors influencing nuclear gene expression.

Mechanism of homology search expansion during recombinational DNA break repair

This paper investigates the mechanism of homology search expansion during DNA break repair, revealing how chromatin structure, NPF stiffening, and resection drive genome-wide search.

Translation-dependent and independent mRNA decay occur through mutually exclusive pathways that are defined by ribosome density during T Cell activation.

The paper shows that mRNA decay during T cell activation occurs through translation-dependent and independent pathways, with ribosome density determining the pathway used.

Interplay between coding and exonic splicing regulatory sequences

The paper shows that exons regulated by the same splicing factor share similar nucleotide composition and code for amino acids with similar physicochemical properties.

Interplay between gene nucleotide composition bias and splicing

The paper identifies GC-rich and AT-rich exons with distinct splicing factor dependencies and shows how nucleotide composition bias influences chromatin organization and exon recognition during splicing.

Probabilistic Count Matrix Factorization for Single Cell Expression Data Analysis

The paper introduces a probabilistic Count Matrix Factorization method for single-cell expression data analysis, showing improved clustering performance compared to existing methods.

Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

This study shows condensin affects RNA levels by causing chromosome missegregation, not by directly regulating transcription.